An Epidemiological Model on the Impact of Relapse in Patients With chronic Hepatitis B Virus Infection, using Treatment Strategies as Control

Abstract

The Impact of Relapse in Patients With chronic Hepatitis B Virus Infection, using Treatment Strategies as Control is analyzed. The reproduction number is computed from which threshold ratios are obtained. Sensitivity indices of the effective reproduction number, establishes that, the transmission rate championed the disease outbreak. Numerical experiments were carried out using MATLAB program, the result uncovers that ineffective treatment slows down the capability of recovery from the disease and should be avoided to reduce the consequences of drug resistance. On the other hand, people that have adopted effective treatment strategies have shown greater potentials for recuperation from the infection. Also, new drugs with low resistance should be given, that will help to reduce the risk of relapse. Hence, compliance to highly effective treatment strategy is needed to control relapse in patients with persistent HBV infection.