Review on the Emergence of Quinolone Resistance Against Salmonella Typhi in Nigeria

Abstract

Typhoid fever is a febrile illness caused by Salmonella species (Enterica serovars typhi). Typhoid fever is primarily transmitted through contaminated water or food. Quinolones are one of the most commonly prescribed antibacterial classes used for the treatment of different bacterial infections in humans including typhoid fever. Due to the widespread use of these drugs, the number of quinolone-resistant bacterial strains are increasing all the time. Salmonella resistance mechanisms to the quinolone antibiotic class have become increasingly complex, attracting global attention. Studies on Salmonella resistance to the quinolone class of antibiotics are not well reported in Nigeria. This information is scanty or completely not covered the Northern parts of Nigeria in the available literature. As a result, this review discusses previous and current research on Salmonella resistance to a class of quinolone antimicrobial drugs in Nigeria.